Intramitochondrial localization of kynurenine aminotransferase.

Comparisons with the distribution of intramitochondrial marker enzymes have indicated that kynurenine aminotransferase is present in the inner membrane fraction of rat liver mitochondria. It appears to be weakly bound to the inner membrane because it is easily solubilized by increasing the concentration of digitonin. With the use of a-ketoglutarate or oxalacetate as amino group acceptor, the aminotransferase has been found to transaminate 3-hydroxy-Lkynurenine as well as L-kynurenine.